CVS Practice Test 2025 – Complete Exam Preparation

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What is the resting membrane potential (RMP) of non-pacemaker action potentials?

-60 mV

-80 mV

-90 mV

The resting membrane potential (RMP) of non-pacemaker action potentials is typically around -90 mV. This value is primarily influenced by the permeability of the cell membrane to potassium ions (K+). In non-pacemaker cells, the high permeability to K+ allows these ions to flow out of the cell, which establishes a negative charge inside compared to the outside.

The RMP can fluctuate based on various factors, such as ion concentrations and membrane permeability, but a typical value for non-pacemaker cardiac cells is approximately -90 mV due to their stable K+ conductance. This value is critical for the generation of action potentials, as it provides the necessary polarization to allow for the depolarization that occurs during action potentials.

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-70 mV

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